Seizure Aggravation—Evidence that Oxcarbazepine Requires Monitoring
نویسندگان
چکیده
منابع مشابه
A Smell That Causes Seizure
In mammals, odorants are detected by a large family of receptors that are each expressed in just a small subset of olfactory sensory neurons (OSNs). Here we describe a strain of transgenic mice engineered to express an octanal receptor in almost all OSNs. Remarkably, octanal triggered a striking and involuntary phenotype in these animals, with passive exposure regularly inducing seizures. Octan...
متن کاملDrug monitoring and toxicology: a procedure for the monitoring of oxcarbazepine metabolite by HPLC-UV.
This article describes a rapid high-performance liquid chromatographic (HPLC) method for the measurement of the primary metabolite of oxcarbazepine. Following a simple precipitation step, 10,11,-dihydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide is quantitated (5-60 microg/mL) by analysis on an HPLC-UV system. The instrument time is less than 5 min per injection, an improvement over most p...
متن کاملLimitations of Motor Seizure Monitoring in Ect
Seizures were monitored using both cuff method and EEG, during the first ECT session in 158 consecutive patients. All developed adequate EEG seizures (≥25 seconds). Twelve patients (8%) did not develop adequate motor seizures (15 seconds), of whom ten had no convulsive response. EEG seizure duration was less than 120 seconds in 117 patients (Group-A) and 120 or more seconds (prolonged) in the r...
متن کاملClinical recommendations for oxcarbazepine
Oxcarbazepine (OXC) is indicated for treating partial-onset with or without secondary generalized tonic-clonic seizures, in both adults and children aged over 6 years, as monotherapy or adjuvant therapy. Trials data and extensive clinical experience demonstrate generally good tolerability and antiepileptic efficacy similar to carbamazepine (CBZ), sodium valproate or phenytoin. Since the UK laun...
متن کاملOxcarbazepine: a review
Oxcarbazepine recently gained a licence in the UK and USA. The purpose of this article is to review the pharmacology and therapeutics of oxcarbazepine for those prescribers unfamiliar with this interesting new antiepileptic drug1–3. Although only newly licensed in the UK and USA, oxcarbazepine has in fact been in routine clinical use in Denmark and other countries for up to 10 years, and experi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2008
ISSN: 1535-7597,1535-7511
DOI: 10.1111/j.1535-7511.2008.00252.x